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Biblioteca (s) : |
INIA Tacuarembó. |
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Fecha : |
23/10/2020 |
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Actualizado : |
23/10/2020 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
MACHADO, M.; DE MACÊDO PESSOA, C.R.; PESSOA, A. F. A.; SOUZA MENDES, R. DE; MEDEIROS, R. M. T. DE; DANTAS, A. F. M.; CASTRO, M. B. DE; RIET-CORREA, F. |
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Afiliación : |
MIZAEL MACHADO DA COSTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CLARICE RICARDO DE MACÊDO PESSOA, Universidade Federal de Sergipe (UFS), Campus do Sertão, Nossa Senhora da Glória, SE, Brazil; ANDRÉ FLÁVIO ALMEIDA PESSOA, Universidade Federal de Sergipe (UFS), Campus do Sertão, Nossa Senhora da Glória, SE, Brazil; RODRIGO DE SOUZA MENDES, Escola de Saúde, Universidade Potiguar (UnP), Natal, RN, Brazil. 4 Centro de Saúde e Tecnologia Rural (CSTR), Universidade Federal de Campina Grande (UFCG), Patos, PB, Brazil; ANTÔNIO FLÁVIO MEDEIROS DANTAS, Centro de Saúde e Tecnologia Rural (CSTR), Universidade Federal de Campina Grande (UFCG), Patos, PB, Brazil; ANTÔNIO FLÁVIO MEDEIROS DANTAS, Centro de Saúde e Tecnologia Rural (CSTR), Universidade Federal de Campina Grande (UFCG), Patos, PB, Brazil; MÁRCIO BOTELHO DE CASTRO, Laboratório de Patologia Veterinária, H.V., Universidade de Brasília (UnB), Brasília, DF, Brazil; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
South American rattlesnake (Crotalus durissus spp.) envenomation in dogs in the semiarid region of Brazil. |
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Fecha de publicación : |
2020 |
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Fuente / Imprenta : |
Acta Scientiae Veterinariae, 2020, Volume 48, Article number 521. DOI: https://doi.org/10.22456/1679-9216.104578 |
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DOI : |
10.22456/1679-9216.104578 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received: 29 March 2020 Accepted: 17 June 2020 Published: 19 July 2020. Acknowledgments: Thanks are due to Dr. José María Gutiérrez (University of Costa Rica) for the critical reading of the manuscript and suggestions. |
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Contenido : |
ABSTRACT: Background: South American rattlesnake (Crotalus durissus spp.) envenomation is rarely reported in small animals and livestock in Brazil. Minor swelling at the snakebite site, skeletal muscle, and renal damage, and severe neurological signs characterize the crotalic envenomation. This case report aims to present epidemiological, clinical, and pathological data of two cases of Crotalus durissus spp envenomation in dogs in the Northeast of Brazil. Cases: Envenomation by Crotalus durissus spp. was recorded in two dogs in Patos, State of Paraíba, Brazil. In Case 1, the dog presented flaccid paralysis, hyporeflexia, a deficit of cranial nerves, epistaxis, and gingival hemorrhages. Laboratory assay showed proteinuria, myoglobinuria, regenerative thrombocytopenia, and increased serum activities of creatine kinase (CK), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). The dog was medicated with crotalic antivenom and wholly recovered from local and systemic clinical signs. In Case 2, the dog died and was detected fang marks at the ventral region of the left mandible (two small parallel perforations spaced 2.0 cm apart) at the snakebite site. Cyanosis of the oral cavity, congestion, and hemorrhages in several organs were observed at necropsy. Tubular nephrosis, muscular necrosis, hepatocytes swelling were observed. The owners witnessed snakebites, and the rattlesnakes (Crotalus durissus spp.) identified by the rattle at the end portion of the tail in both cases. Discussion: Natural South American rattlesnake envenomation presents complex clinical signs that makes diagnosis a challenge for veterinary practitioners. The criteria for the correct diagnosis and observed in the two dogs include witness of the snakebite, identification of the snake, detection of fang marks, clinical-pathological findings, and therapeutic response to treatment with specific anti-venom. The dog’s owners did not identify the subspecies of rattlesnakes; however, Crotalus durissus cascavella and Crotalus durissus collilineatus are the only species found in the Northeast region of Brazil. Crotoxin is the primary toxic component of South American rattlesnake, which induces neuromuscular blockage, and neurological signs (skeletal muscle flaccid paralysis, apathy, hyporeflexia, cranial nerve deficits). These clinical signs are similar to those observed in the two dogs. Respiratory distress, cyanosis, pulmonary edema, and hemorrhage are secondary to respiratory muscle paralysis and also detected in a dog (Case 2) with crotalic envenomation. Minor local swelling at the snakebite site, myotoxicity observed in both dogs (high serum activities of CK and AST - Case 1), degeneration
and necrosis of muscle fibers - Case 2), and fang marks observed in Case 2, strengthen the diagnosis of Crotalus durissus envenomation. Nephrotoxicity was also detected in both dogs (increased specific gravity of urine - Case 1 and myoglobin deposition and degeneration of renal epithelial tubular cells - Case 2). Coagulative disorders and hepatotoxicity are infrequently in domestic animals and humans with crotalic envenomation. High serum activities of ALP and ALT in Case 1, and swelling of hepatocytes in Case 2, suggest liver damage associated with the crotalic envenomation. The differential diagnosis of South American rattlesnake envenomation should be included in dogs with acute neuromuscular flaccid
paralysis, associated or not with bleeding disorders, myoglobinuria, and acute kidney injury. MenosABSTRACT: Background: South American rattlesnake (Crotalus durissus spp.) envenomation is rarely reported in small animals and livestock in Brazil. Minor swelling at the snakebite site, skeletal muscle, and renal damage, and severe neurological signs characterize the crotalic envenomation. This case report aims to present epidemiological, clinical, and pathological data of two cases of Crotalus durissus spp envenomation in dogs in the Northeast of Brazil. Cases: Envenomation by Crotalus durissus spp. was recorded in two dogs in Patos, State of Paraíba, Brazil. In Case 1, the dog presented flaccid paralysis, hyporeflexia, a deficit of cranial nerves, epistaxis, and gingival hemorrhages. Laboratory assay showed proteinuria, myoglobinuria, regenerative thrombocytopenia, and increased serum activities of creatine kinase (CK), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). The dog was medicated with crotalic antivenom and wholly recovered from local and systemic clinical signs. In Case 2, the dog died and was detected fang marks at the ventral region of the left mandible (two small parallel perforations spaced 2.0 cm apart) at the snakebite site. Cyanosis of the oral cavity, congestion, and hemorrhages in several organs were observed at necropsy. Tubular nephrosis, muscular necrosis, hepatocytes swelling were observed. The owners witnessed snakebites, and the rattlesnakes (Crotalus durissus spp.) identified by the rattle at the e... Presentar Todo |
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Palabras claves : |
CROTALIC ENVENOMATION; CROTALUS DURISSUS SPP; DOG; SNAKEBITE; TOXIC MYOPATHY. |
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Asunto categoría : |
L70 Ciencias veterinarias e higiene - Aspectos generales |
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Marc : |
LEADER 04714naa a2200289 a 4500
001 1061423
005 2020-10-23
008 2020 bl uuuu u00u1 u #d
024 7 $a10.22456/1679-9216.104578$2DOI
100 1 $aMACHADO, M.
245 $aSouth American rattlesnake (Crotalus durissus spp.) envenomation in dogs in the semiarid region of Brazil.$h[electronic resource]
260 $c2020
500 $aArticle history: Received: 29 March 2020 Accepted: 17 June 2020 Published: 19 July 2020. Acknowledgments: Thanks are due to Dr. José María Gutiérrez (University of Costa Rica) for the critical reading of the manuscript and suggestions.
520 $aABSTRACT: Background: South American rattlesnake (Crotalus durissus spp.) envenomation is rarely reported in small animals and livestock in Brazil. Minor swelling at the snakebite site, skeletal muscle, and renal damage, and severe neurological signs characterize the crotalic envenomation. This case report aims to present epidemiological, clinical, and pathological data of two cases of Crotalus durissus spp envenomation in dogs in the Northeast of Brazil. Cases: Envenomation by Crotalus durissus spp. was recorded in two dogs in Patos, State of Paraíba, Brazil. In Case 1, the dog presented flaccid paralysis, hyporeflexia, a deficit of cranial nerves, epistaxis, and gingival hemorrhages. Laboratory assay showed proteinuria, myoglobinuria, regenerative thrombocytopenia, and increased serum activities of creatine kinase (CK), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). The dog was medicated with crotalic antivenom and wholly recovered from local and systemic clinical signs. In Case 2, the dog died and was detected fang marks at the ventral region of the left mandible (two small parallel perforations spaced 2.0 cm apart) at the snakebite site. Cyanosis of the oral cavity, congestion, and hemorrhages in several organs were observed at necropsy. Tubular nephrosis, muscular necrosis, hepatocytes swelling were observed. The owners witnessed snakebites, and the rattlesnakes (Crotalus durissus spp.) identified by the rattle at the end portion of the tail in both cases. Discussion: Natural South American rattlesnake envenomation presents complex clinical signs that makes diagnosis a challenge for veterinary practitioners. The criteria for the correct diagnosis and observed in the two dogs include witness of the snakebite, identification of the snake, detection of fang marks, clinical-pathological findings, and therapeutic response to treatment with specific anti-venom. The dog’s owners did not identify the subspecies of rattlesnakes; however, Crotalus durissus cascavella and Crotalus durissus collilineatus are the only species found in the Northeast region of Brazil. Crotoxin is the primary toxic component of South American rattlesnake, which induces neuromuscular blockage, and neurological signs (skeletal muscle flaccid paralysis, apathy, hyporeflexia, cranial nerve deficits). These clinical signs are similar to those observed in the two dogs. Respiratory distress, cyanosis, pulmonary edema, and hemorrhage are secondary to respiratory muscle paralysis and also detected in a dog (Case 2) with crotalic envenomation. Minor local swelling at the snakebite site, myotoxicity observed in both dogs (high serum activities of CK and AST - Case 1), degeneration and necrosis of muscle fibers - Case 2), and fang marks observed in Case 2, strengthen the diagnosis of Crotalus durissus envenomation. Nephrotoxicity was also detected in both dogs (increased specific gravity of urine - Case 1 and myoglobin deposition and degeneration of renal epithelial tubular cells - Case 2). Coagulative disorders and hepatotoxicity are infrequently in domestic animals and humans with crotalic envenomation. High serum activities of ALP and ALT in Case 1, and swelling of hepatocytes in Case 2, suggest liver damage associated with the crotalic envenomation. The differential diagnosis of South American rattlesnake envenomation should be included in dogs with acute neuromuscular flaccid paralysis, associated or not with bleeding disorders, myoglobinuria, and acute kidney injury.
653 $aCROTALIC ENVENOMATION
653 $aCROTALUS DURISSUS SPP
653 $aDOG
653 $aSNAKEBITE
653 $aTOXIC MYOPATHY
700 1 $aDE MACÊDO PESSOA, C.R.
700 1 $aPESSOA, A. F. A.
700 1 $aSOUZA MENDES, R. DE
700 1 $aMEDEIROS, R. M. T. DE
700 1 $aDANTAS, A. F. M.
700 1 $aCASTRO, M. B. DE
700 1 $aRIET-CORREA, F.
773 $tActa Scientiae Veterinariae, 2020, Volume 48, Article number 521. DOI: https://doi.org/10.22456/1679-9216.104578
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Registro original : |
INIA Tacuarembó (TBO) |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
29/04/2015 |
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Actualizado : |
15/10/2019 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
B - 1 |
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Autor : |
GRASSO, A.; GOLDBERG, V.; NAVAJAS, E.; IRIARTE, W.; GIMENO, D.; AGUILAR, I.; MEDRANO, J.F.; RINCÓN, G.; CIAPPESONI, G. |
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Afiliación : |
ANDRES NICOLAS GRASSO PALAS, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; VIRGINIA GOLDBERG BIANCHI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ELLY ANA NAVAJAS VALENTINI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; WANDA IRIARTE GRECO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; DIEGO GIMENO, SUL (Secretariado Uruguayo de la Lana).; IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JUAN F. MEDRANO, Universidad de California Davis (UCD); GONZALO RINCÓN, Universidad de California Davis (UCD); CARLOS GABRIEL CIAPPESONI SCARONE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Genomic variation and population structure detected by single nucleotide polymorphism arrays in Corriedale, Merino and Creole sheep. |
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Fecha de publicación : |
2014 |
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Fuente / Imprenta : |
Genetics and Molecular Biology, 2014, v.37, n.2, p.389-395. |
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DOI : |
10.1590/S1415-47572014000300011 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received: August 29, 2013 / Accepted: March 16, 2014. |
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Contenido : |
ABSTRACT.
The aim of this study was to investigate the genetic diversity within and among three breeds of sheep: Corriedale, Merino and Creole. Sheep from the three breeds (Merino n = 110, Corriedale n = 108 and Creole n = 10) were genotyped using the Illumina Ovine SNP50 beadchip®
. Genetic diversity was evaluated by comparing the minor allele frequency (MAF) among breeds. Population structure and genetic differentiation were assessed using STRUCTURE software, principal component analysis (PCA) and fixation index (FST). Fixed markers (MAF = 0) that were different
among breeds were identified as specific breed markers. Using a subset of 18,181 single nucleotide polymorphisms (SNPs), PCA and STUCTURE analysis were able to explain population stratification within breeds. Merino and Corriedale divergent lines showed high levels of polymorphism (89.4% and 86% of polymorphic SNPs, respectively) and moderate genetic differentiation (FST = 0.08) between them. In contrast, Creole had only 69% polymorphic SNPs and
showed greater genetic differentiation from the other two breeds (FST = 0.17 for both breeds). Hence, a subset of molecular markers present in the OvineSNP50 is informative enough for breed assignment and population structure analysis of commercial and Creole breeds. |
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Palabras claves : |
OVINE SNP50. |
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Thesagro : |
DIVERSIDAD GENETICA; OVEJA; OVINOS; RAZAS (ANIMALES). |
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Asunto categoría : |
L10 Genética y mejoramiento animal |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/4414/1/Grasso-N.-2014.-Genetcs-and-Mol.Biol.v37n2.pdf
http://www.scielo.br/pdf/gmb/v37n2/a11v37n2.pdf
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Marc : |
LEADER 02237naa a2200301 a 4500
001 1052592
005 2019-10-15
008 2014 bl uuuu u00u1 u #d
024 7 $a10.1590/S1415-47572014000300011$2DOI
100 1 $aGRASSO, A.
245 $aGenomic variation and population structure detected by single nucleotide polymorphism arrays in Corriedale, Merino and Creole sheep.$h[electronic resource]
260 $c2014
500 $aArticle history: Received: August 29, 2013 / Accepted: March 16, 2014.
520 $aABSTRACT. The aim of this study was to investigate the genetic diversity within and among three breeds of sheep: Corriedale, Merino and Creole. Sheep from the three breeds (Merino n = 110, Corriedale n = 108 and Creole n = 10) were genotyped using the Illumina Ovine SNP50 beadchip® . Genetic diversity was evaluated by comparing the minor allele frequency (MAF) among breeds. Population structure and genetic differentiation were assessed using STRUCTURE software, principal component analysis (PCA) and fixation index (FST). Fixed markers (MAF = 0) that were different among breeds were identified as specific breed markers. Using a subset of 18,181 single nucleotide polymorphisms (SNPs), PCA and STUCTURE analysis were able to explain population stratification within breeds. Merino and Corriedale divergent lines showed high levels of polymorphism (89.4% and 86% of polymorphic SNPs, respectively) and moderate genetic differentiation (FST = 0.08) between them. In contrast, Creole had only 69% polymorphic SNPs and showed greater genetic differentiation from the other two breeds (FST = 0.17 for both breeds). Hence, a subset of molecular markers present in the OvineSNP50 is informative enough for breed assignment and population structure analysis of commercial and Creole breeds.
650 $aDIVERSIDAD GENETICA
650 $aOVEJA
650 $aOVINOS
650 $aRAZAS (ANIMALES)
653 $aOVINE SNP50
700 1 $aGOLDBERG, V.
700 1 $aNAVAJAS, E.
700 1 $aIRIARTE, W.
700 1 $aGIMENO, D.
700 1 $aAGUILAR, I.
700 1 $aMEDRANO, J.F.
700 1 $aRINCÓN, G.
700 1 $aCIAPPESONI, G.
773 $tGenetics and Molecular Biology, 2014$gv.37, n.2, p.389-395.
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